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Feb

17

Small Molecule Compounds and the NF-κB Signaling Pathway

nf-kb-pathway

Small Molecule Compounds and the NF-κB Signaling Pathway

Nuclear factor-kappa B (NF-κB) is an ancient protein transcription factor and considered a regulator of innate immunity. NF-κB is found in almost all animal cell types. In mammals, the NF-κB family is composed of five related transcription factors: p50, p52, RelA (p65), c-Rel, and RelB. NF-κB controls the expression of genes involved in a number of physiological responses, including immune-inflammatory responses, acute-phase inflammatory responses, oxidative stress responses, cell adhesion, differentiation, and apoptosis.

Jan

10

Small Molecule Compounds Targeting Cyclin-Dependent Kinases

cyclin-dependent-kinases

Small Molecule Compounds Targeting Cyclin-Dependent Kinases

Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose activity depends on a regulatory subunit - a cyclin. Based on the sequence of the kinase domain, CDKs belong to the CMGC group of kinases (named for the initials of some members), along with mitogen-activated protein kinases (MAPKs), glycogen synthase kinase-3 beta (Gsk3β), members of the dual-specificity tyrosine-regulated kinase (DYRK) family and CDK-like kinases. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain.

Nov

19

New Strategy for Synthesizing the Natural Compound Himastatin

himastatin

New Strategy for Synthesizing the Natural Compound Himastatin

Oct

29

An Orally Active, Small-molecule Approach to Boost Important Protein That May Protect Against Aspects of Aging

cellular-senescence

An Orally Active, Small-molecule Approach to Boost Important Protein That May Protect Against Aspects of Aging

Klotho is an enzyme that in humans is encoded by the KL gene. There are three subfamilies of klotho: α-klotho, β-klotho, and γ-klotho. α-klotho is highly expressed in the brain and liver. α-Klotho is a geroprotective factor that exerts anti-physiological stress effects and protects against oxidative damage, hypoxia, and cytotoxic drugs. α-klotho, which binds to the endocrine FGF FGF23 changes cellular calcium homeostasis, by both increasing the expression and activity of TRPV5 (decreasing phosphate reabsorption in the kidney) and decreasing that of TRPC6 (decreasing phosphate absorption from the intestine).

Oct

19

Olaparib Added to Standard Treatment Boosts Survival in Patients with Inherited BRCA Mutations

parp-inhibitors-antagonists

Olaparib Added to Standard Treatment Boosts Survival in Patients with Inherited BRCA Mutations

Oct

13

Small Molecule Immunomodulation in Cancer

immunomodulation

Small Molecule Immunomodulation in Cancer

Cytotoxic chemotherapies have traditionally been used to treat advanced solid tumors, but these are generally non-curative, are associated with significant toxicities and do not produce durable response rates. There is increasing interest in the role of immunotherapy as an attractive strategy in the management of advanced solid tumors previously assumed to be non-immunogenic.

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